Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003165)
Formula Reactant Hydroxyphenytoin Product Hydroxyphenytoin-O-glucuronide metabolite
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002029 Phenytoin arene-oxide Hydroxyphenytoin Unclear Phenytoin [1]
MR003162 Phenytoin arene-oxide Hydroxyphenytoin Unclear Fosphenytoin sodium [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002031 Hydroxyphenytoin 4-hydroxyphenytoin o-glucuronide Conjugation - O-Glucuronidation Phenytoin [1], [2]
MR002030 Hydroxyphenytoin Phenytoin catechol Oxidation - Oxidation Phenytoin [1]
MR003164 Hydroxyphenytoin Phenytoin catechol Oxidation - Oxidation Fosphenytoin sodium [1]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 Biotransformation of phenytoin in the electrochemically-driven CYP2C19 system. Biophys Chem. 2022 Dec;291:106894. doi: 10.1016/j.bpc.2022.106894.

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