Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002032)
Formula
SVG example
Methylation
Reactant Phenytoin catechol Product Phenytoin methylcatechol
Reactant Info Product Info
Metabolic Enzyme Catechol O-methyltransferase (COMT) DME Info
Metabolic Type Conjugation - Methylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002034 Phenytoin dihydrodiol Phenytoin catechol Unclear Phenytoin [1]
MR002030 Hydroxyphenytoin Phenytoin catechol Oxidation - Oxidation Phenytoin [2]
MR003164 Hydroxyphenytoin Phenytoin catechol Oxidation - Oxidation Fosphenytoin sodium [2]
MR003169 Phenytoin dihydrodiol Phenytoin catechol Unclear Fosphenytoin sodium [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002033 Phenytoin catechol Phenytoin quinone Oxidation - Oxidation Phenytoin [2]
MR003167 Phenytoin catechol Phenytoin quinone Oxidation - Oxidation Fosphenytoin sodium [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003168 Phenytoin methylcatechol Phenytoin quinone Oxidation - Oxidation Fosphenytoin sodium [3]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
3 DrugBank(Pharmacology-Metabolism)Fosphenytoin sodium

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