Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002033)
Formula
SVG example
Oxidation
Reactant Phenytoin catechol Product Phenytoin quinone
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002034 Phenytoin dihydrodiol Phenytoin catechol Unclear Phenytoin [1]
MR002030 Hydroxyphenytoin Phenytoin catechol Oxidation - Oxidation Phenytoin [2]
MR003164 Hydroxyphenytoin Phenytoin catechol Oxidation - Oxidation Fosphenytoin sodium [2]
MR003169 Phenytoin dihydrodiol Phenytoin catechol Unclear Fosphenytoin sodium [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002032 Phenytoin catechol Phenytoin methylcatechol Conjugation - Methylation Phenytoin [2]
MR003166 Phenytoin catechol Phenytoin methylcatechol Conjugation - Methylation Fosphenytoin sodium [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003168 Phenytoin methylcatechol Phenytoin quinone Oxidation - Oxidation Fosphenytoin sodium [3]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
3 DrugBank(Pharmacology-Metabolism)Fosphenytoin sodium

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