Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002054)
Formula
CYP3A4 ...
SVG example
Oxidation
Reactant Pioglitazone hydrochloride Product Pioglitazone metabolite M-IV
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002050 Pioglitazone hydrochloride Pioglitazone metabolite M-I Oxidation - O-Dealkylation Pioglitazone hydrochloride [1], [2]
MR002051 Pioglitazone hydrochloride Pioglitazone metabolite M-II Oxidation - Oxidation Pioglitazone hydrochloride [1], [2]
MR002053 Pioglitazone hydrochloride Pioglitazone metabolite M-V Oxidation - Oxidation Pioglitazone hydrochloride [1], [2]
MR002052 Pioglitazone hydrochloride Pioglitazone metabolite M-VI Oxidation - Oxidation Pioglitazone hydrochloride [1]
MR002055 Pioglitazone hydrochloride Pioglitazone metabolite M-VII Oxidation - Hydroxylation Pioglitazone hydrochloride [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002049 Pioglitazone metabolite M-IV Pioglitazone metabolite M-III Oxidation - Oxidation Pioglitazone hydrochloride [1], [2]
MR002048 Pioglitazone metabolite M-IV Pioglitazone metabolite M-XI Oxidation - Oxidation Pioglitazone hydrochloride [1], [2]
References
1 Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro: potential for interactions with CYP2C8 inhibitors. Basic Clin Pharmacol Toxicol. 2006 Jul;99(1):44-51.
2 Simultaneous quantitation of pioglitazone and its metabolites in human serum by liquid chromatography and solid phase extraction J Pharm Biomed Anal. 1996 Feb;14(4):465-73. doi: 10.1016/0731-7085(95)01665-1.
3 Identification of novel metabolites of pioglitazone in rat and dog Xenobiotica. 2003 May;33(5):499-509. doi: 10.1080/0049825031000085951.

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