Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002152)
Formula
SVG example
Hydroxylation
Reactant Probenecid Product 2-hydroxy Probenecid
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002153 Probenecid Mono-N-DepropylProbenecid Oxidation - Deethylation Probenecid [1], [2]
MR002151 Probenecid Probenecid acyl glucuronide Conjugation - Glucuronidation Probenecid [3], [2]
MR002154 Probenecid Probenecid metabolite M1 Oxidation - Hydroxylation Probenecid [1], [2]
MR002155 Probenecid Probenecid metabolite M2 Oxidation - Oxidation Probenecid [1], [2]
References
1 Clinical pharmacokinetics of probenecid Clin Pharmacokinet. 1981 Mar-Apr;6(2):135-51. doi: 10.2165/00003088-198106020-00004.
2 The metabolism of probenecid in man Ann N Y Acad Sci. 1971 Jul 6;179:399-402. doi: 10.1111/j.1749-6632.1971.tb46916.x.
3 Modulation of 3'-azido-3'-deoxythymidine catabolism by probenecid and acetaminophen in freshly isolated rat hepatocytes. Biochem Pharmacol. 1991 Sep 12;42(7):1475-80.

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