Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002153)
Formula
SVG example
Deethylation
Reactant Probenecid Product Mono-N-DepropylProbenecid
Reactant Info Product Info
Metabolic Type Oxidation - Deethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002152 Probenecid 2-hydroxy Probenecid Oxidation - Hydroxylation Probenecid [1], [2]
MR002151 Probenecid Probenecid acyl glucuronide Conjugation - Glucuronidation Probenecid [3], [2]
MR002154 Probenecid Probenecid metabolite M1 Oxidation - Hydroxylation Probenecid [1], [2]
MR002155 Probenecid Probenecid metabolite M2 Oxidation - Oxidation Probenecid [1], [2]
References
1 Clinical pharmacokinetics of probenecid Clin Pharmacokinet. 1981 Mar-Apr;6(2):135-51. doi: 10.2165/00003088-198106020-00004.
2 The metabolism of probenecid in man Ann N Y Acad Sci. 1971 Jul 6;179:399-402. doi: 10.1111/j.1749-6632.1971.tb46916.x.
3 Modulation of 3'-azido-3'-deoxythymidine catabolism by probenecid and acetaminophen in freshly isolated rat hepatocytes. Biochem Pharmacol. 1991 Sep 12;42(7):1475-80.

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