Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR002154)
Formula	Hydroxylation
	Reactant	Probenecid		Product	Probenecid metabolite M1
	Reactant	Reactant Info		Product	Product Info
Metabolic Type	Oxidation - Hydroxylation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR002152	Probenecid	2-hydroxy Probenecid	Oxidation - Hydroxylation	Probenecid	[1], [2]
MR002153	Probenecid	Mono-N-DepropylProbenecid	Oxidation - Deethylation	Probenecid	[1], [2]
MR002151	Probenecid	Probenecid acyl glucuronide	Conjugation - Glucuronidation	Probenecid	[3], [2]
MR002155	Probenecid	Probenecid metabolite M2	Oxidation - Oxidation	Probenecid	[1], [2]

References
1	Clinical pharmacokinetics of probenecid Clin Pharmacokinet. 1981 Mar-Apr;6(2):135-51. doi: 10.2165/00003088-198106020-00004.
2	The metabolism of probenecid in man Ann N Y Acad Sci. 1971 Jul 6;179:399-402. doi: 10.1111/j.1749-6632.1971.tb46916.x.
3	Modulation of 3'-azido-3'-deoxythymidine catabolism by probenecid and acetaminophen in freshly isolated rat hepatocytes. Biochem Pharmacol. 1991 Sep 12;42(7):1475-80.

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