Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR002157)
Formula	Deethylation
	Reactant	Procainamide hydrochloride		Product	Desethylprocainamide
	Reactant	Reactant Info		Product	Product Info
Metabolic Type	Oxidation - Deethylation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR002156	Procainamide hydrochloride	N-Acetyl-3-hydroxyprocainamide	Oxidation - N-Hydroxylation	Procainamide hydrochloride	[1], [2]
MR002158	Procainamide hydrochloride	Procainamide 4-hydroxylamine	Oxidation - Hydroxylation	Procainamide hydrochloride	[2]

References
1	Involvement of CYP2D6 activity in the N-oxidation of procainamide in man. Pharmacogenetics. 1999 Dec;9(6):683-96.
2	Metabolites of procainamide and practolol inhibit complement components C3 and C4 Biochem J. 1988 Apr 15;251(2):323-6. doi: 10.1042/bj2510323.

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