Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002166)
Formula
CYP2C19 ...
SVG example
N-Demethylation
Reactant Prochlorperazine Product N-demethylation
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002168 Prochlorperazine Prochlorperazine 7-hydroxide Oxidation - 7-Hydroxylation Prochlorperazine [1], [2], [3]
MR002167 Prochlorperazine Prochlorperazine sulfoxide Oxidation - Sulfoxidation Prochlorperazine [1], [2], [3]
MR002169 Prochlorperazine Prochlorperazine sulfoxide 4'-N-oxide Oxidation - Oxidation Prochlorperazine [3]
References
1 Influence of cytochrome P450 genotype on the plasma disposition of prochlorperazine metabolites and their relationships with clinical responses in cancer patients Ann Clin Biochem. 2018 May;55(3):385-393. doi: 10.1177/0004563217731432.
2 Simultaneous determination of prochlorperazine and its metabolites in human plasma using isocratic liquid chromatography tandem mass spectrometry Biomed Chromatogr. 2012 Jun;26(6):754-60. doi: 10.1002/bmc.1725.
3 Bioavailability and metabolism of prochlorperazine administered via the buccal and oral delivery route J Clin Pharmacol. 2005 Dec;45(12):1383-90. doi: 10.1177/0091270005281044.

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