Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002168)
Formula
CYP2C19 ...
SVG example
7-Hydroxylation
Reactant Prochlorperazine Product Prochlorperazine 7-hydroxide
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - 7-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002166 Prochlorperazine N-demethylation Oxidation - N-Demethylation Prochlorperazine [1], [2], [3]
MR002167 Prochlorperazine Prochlorperazine sulfoxide Oxidation - Sulfoxidation Prochlorperazine [1], [2], [3]
MR002169 Prochlorperazine Prochlorperazine sulfoxide 4'-N-oxide Oxidation - Oxidation Prochlorperazine [3]
References
1 Influence of cytochrome P450 genotype on the plasma disposition of prochlorperazine metabolites and their relationships with clinical responses in cancer patients Ann Clin Biochem. 2018 May;55(3):385-393. doi: 10.1177/0004563217731432.
2 Simultaneous determination of prochlorperazine and its metabolites in human plasma using isocratic liquid chromatography tandem mass spectrometry Biomed Chromatogr. 2012 Jun;26(6):754-60. doi: 10.1002/bmc.1725.
3 Bioavailability and metabolism of prochlorperazine administered via the buccal and oral delivery route J Clin Pharmacol. 2005 Dec;45(12):1383-90. doi: 10.1177/0091270005281044.

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