Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002182)
Formula Reactant Promethazine Product Promethazine Hydroxy metabolite
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002181 Promethazine Desmethylpromethazine Oxidation - N-Demethylation Promethazine [1], [2]
MR002180 Promethazine Promethazine Sulphoxide Oxidation - Sulphoxidation Promethazine [1], [2], [3]
References
1 An HPLC-ESI-MS method for simultaneous determination of fourteen metabolites of promethazine and caffeine and its application to pharmacokinetic study of the combination therapy against motion sickness J Pharm Biomed Anal. 2012 Mar 25;62:119-28. doi: 10.1016/j.jpba.2011.12.033.
2 A liquid chromatographic method for the simultaneous determination of promethazine and three of its metabolites in plasma using electrochemical and UV detectors J Chromatogr Sci. 2001 Feb;39(2):70-2. doi: 10.1093/chromsci/39.2.70.
3 CYP2D6 is the principal cytochrome P450 responsible for metabolism of the histamine H1 antagonist promethazine in human liver microsomes. Pharmacogenetics. 1996 Oct;6(5):449-57.

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