Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002192)
Formula
SVG example
N-Desisopropylation
Reactant Propranolol hydrochloride Product N-desisopropylpropranolol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - N-Desisopropylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002194 Propranolol hydrochloride 1-Naphthol Unclear Propranolol hydrochloride [1]
MR002195 Propranolol hydrochloride 4'-hydroxypropanolol Oxidation - 4-Hydroxylation Propranolol hydrochloride [2], [3]
MR002196 Propranolol hydrochloride Alpha-Naphthoxylactic Acid Oxidation - Oxidation Propranolol hydrochloride [4]
MR002193 Propranolol hydrochloride Propranolol glucuronide Conjugation - O-Glucuronidation Propranolol hydrochloride [4]
References
1 Propranolol metabolism in man and dog: mass spectrometric identification of six new metabolites J Pharmacol Exp Ther. 1972 Jul;182(1):83-92.
2 Isolation, purification, and structure identification of glucuronic acid conjugates of propranolol and alprenolol and their ring-hydroxylated metabolites Drug Metab Dispos. 1984 Nov-Dec;12(6):749-54.
3 Rapid and simultaneous extraction of propranolol, its neutral and basic metabolites from plasma and assay by high-performance liquid chromatography J Chromatogr. 1985 Oct 11;343(2):349-58. doi: 10.1016/s0378-4347(00)84603-4.
4 Propranolol metabolism in normal subjects: association with sex steroid hormones Clin Pharmacol Ther. 1994 Aug;56(2):127-32. doi: 10.1038/clpt.1994.115.

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