Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002195)
Formula
SVG example
4-Hydroxylation
Reactant Propranolol hydrochloride Product 4'-hydroxypropanolol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - 4-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002194 Propranolol hydrochloride 1-Naphthol Unclear Propranolol hydrochloride [1]
MR002196 Propranolol hydrochloride Alpha-Naphthoxylactic Acid Oxidation - Oxidation Propranolol hydrochloride [2]
MR002192 Propranolol hydrochloride N-desisopropylpropranolol Oxidation - N-Desisopropylation Propranolol hydrochloride [3]
MR002193 Propranolol hydrochloride Propranolol glucuronide Conjugation - O-Glucuronidation Propranolol hydrochloride [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002189 4'-hydroxypropanolol 4-hydroxyalprenolol glucuronide Conjugation - Glucuronidation Propranolol hydrochloride [4], [3]
MR002190 4'-hydroxypropanolol Naphthalene-1,4-diol Unclear Propranolol hydrochloride [1]
References
1 Propranolol metabolism in man and dog: mass spectrometric identification of six new metabolites J Pharmacol Exp Ther. 1972 Jul;182(1):83-92.
2 Propranolol metabolism in normal subjects: association with sex steroid hormones Clin Pharmacol Ther. 1994 Aug;56(2):127-32. doi: 10.1038/clpt.1994.115.
3 Rapid and simultaneous extraction of propranolol, its neutral and basic metabolites from plasma and assay by high-performance liquid chromatography J Chromatogr. 1985 Oct 11;343(2):349-58. doi: 10.1016/s0378-4347(00)84603-4.
4 Isolation, purification, and structure identification of glucuronic acid conjugates of propranolol and alprenolol and their ring-hydroxylated metabolites Drug Metab Dispos. 1984 Nov-Dec;12(6):749-54.

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