Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002222)
Formula Reactant Salmeterol xinafoate Product Salmeterol O-dealkylated metabolite
Reactant Info Product Info
Metabolic Type Oxidation - O-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002221 Salmeterol xinafoate Alpha-hydroxysalmeterol Oxidation - Hydroxylation Salmeterol xinafoate [1], [2], [3]
References
1 Determination of salmeterol, -hydroxysalmeterol and fluticasone propionate in human urine and plasma for doping control using UHPLC-QTOF-MS. Biomed Chromatogr. 2021 Aug;35(8):e5114. doi: 10.1002/bmc.5114.
2 Pharmacokinetics of salmeterol and its main metabolite -hydroxysalmeterol after acute and chronic dry powder inhalation in exercising endurance-trained men: Implications for doping control. Drug Test Anal. 2021 Apr;13(4):747-761. doi: 10.1002/dta.2978.
3 The salmeterol anomaly and the need for a urine threshold. Drug Test Anal. 2022 Jun;14(6):997-1003. doi: 10.1002/dta.2810.

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