Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002224)
Formula Reactant Secnidazole Product Hydroxymethyl metabolite of secnidazole
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002225 Secnidazole Glucuronide conjugates of secnidazole Conjugation - Conjugation Secnidazole [1], [2]
References
1 In vitro metabolic profile and drug-drug interaction assessment of secnidazole, a high-dose 5-nitroimidazole antibiotic for the treatment of bacterial vaginosis Pharmacol Res Perspect. 2020 Aug;8(4):e00634. doi: 10.1002/prp2.634.
2 Secnidazole. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic use in the management of protozoal infections and bacterial vaginosis Drugs. 1996 Apr;51(4):621-38. doi: 10.2165/00003495-199651040-00007.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.