Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002242)
Formula Reactant Semaglutide Product P3 semaglutide
Reactant Info Product Info
Metabolic Enzyme Dipeptidyl peptidase IV (DPP4) DME Info
Neprilysin (MME) DME Info
Metabolic Type Oxidation - Hydrolysis; Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002243 Semaglutide . Hydrolysis - Hydrolysis Semaglutide [1]
MR002241 Semaglutide U7 semaglutide Oxidation - Hydrolysis; Oxidation Semaglutide [1]
References
1 Absorption, metabolism and excretion of the GLP-1 analogue semaglutide in humans and nonclinical species. Eur J Pharm Sci. 2017 Jun 15;104:31-41.

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