Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002245)
Formula Reactant Desmethylsertraline Product Alpha-hydroxy sertraline ketone glucuronide
Reactant Info Product Info
Metabolic Type Oxidation - N-Hydroxylation; Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002247 Sertraline hydrochloride Desmethylsertraline Oxidation - N-Demethylation Sertraline hydrochloride [1], [2], [3], [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002244 Desmethylsertraline Alpha-hydroxy sertraline ketone Oxidation - N-Hydroxylation Sertraline hydrochloride [5]
References
1 Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study. Drug Metab Dispos. 2005 Feb;33(2):262-70.
2 Pharmacogenetic Testing and Therapeutic Drug Monitoring Of Sertraline at a Residential Treatment Center for Children and Adolescents: A Pilot Study. Innov Pharm. 2022 Dec 26;13(4):10.24926/iip.v13i4.5035. doi: 10.24926/iip.v13i4.5035.
3 Sertraline. 2022 May 15. Drugs and Lactation Database (LactMed?) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006C.
4 Neonicotinoids and pharmaceuticals in hair of the Red fox (Vulpes vulpes) from the Cavallino-Treporti peninsula, Italy. Environ Res. 2023 Jul 1;228:115837. doi: 10.1016/j.envres.2023.115837.
5 DrugBank(Pharmacology-Metabolism)Sertraline hydrochloride

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