Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002247)
Formula Reactant Sertraline hydrochloride Product Desmethylsertraline
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002244 Desmethylsertraline Alpha-hydroxy sertraline ketone Oxidation - N-Hydroxylation Sertraline hydrochloride [1]
MR002245 Desmethylsertraline Alpha-hydroxy sertraline ketone glucuronide Oxidation - N-Hydroxylation; Glucuronidation Sertraline hydrochloride [2]
References
1 DrugBank(Pharmacology-Metabolism)Sertraline hydrochloride
2 Absorption, metabolism and excretion of the GLP-1 analogue semaglutide in humans and nonclinical species. Eur J Pharm Sci. 2017 Jun 15;104:31-41.

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