Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002258)
Formula
ADH1A ...
SVG example
Dehydrogenation
Reactant Silodosin Product KMD-3293
Reactant Info Product Info
Metabolic Enzyme Alcohol dehydrogenase class-I alpha (ADH1A) DME Info
Aldehyde dehydrogenase 2 (ALDH2) DME Info
Metabolic Type Oxidation - Dehydrogenation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002256 Silodosin KMD-3241 Oxidation - Dehydrogenation Silodosin [1]
MR002259 Silodosin KMD-3289 Oxidation - Dealkylation Silodosin [1]
MR002257 Silodosin Silodosin glucuronide Conjugation - Glucuronidation Silodosin [1]
MR002262 Silodosin Silodosin gluosylated metabolite Conjugation - Glucuronidation Silodosin [1]
MR002263 Silodosin Silodosin hydroxylated metabolite Oxidation - Hydroxylation Silodosin [1]
MR002260 Silodosin Silodosin N-dealkylated metabolite Oxidation - N-Dealkylation Silodosin [1]
MR002261 Silodosin Silodosin sulfated metabolite Conjugation - Sulfation Silodosin [1]
References
1 In vivo metabolic investigation of silodosin using UHPLC-QTOF-MS/MS and in silico toxicological screening of its metabolites J Mass Spectrom. 2016 Oct;51(10):867-882. doi: 10.1002/jms.3795.

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