Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002256)
Formula
ADH1A ...
SVG example
Dehydrogenation
Reactant Silodosin Product KMD-3241
Reactant Info Product Info
Metabolic Enzyme Alcohol dehydrogenase class-I alpha (ADH1A) DME Info
Aldehyde dehydrogenase 2 (ALDH2) DME Info
Metabolic Type Oxidation - Dehydrogenation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002259 Silodosin KMD-3289 Oxidation - Dealkylation Silodosin [1]
MR002258 Silodosin KMD-3293 Oxidation - Dehydrogenation Silodosin [1]
MR002257 Silodosin Silodosin glucuronide Conjugation - Glucuronidation Silodosin [1]
MR002262 Silodosin Silodosin gluosylated metabolite Conjugation - Glucuronidation Silodosin [1]
MR002263 Silodosin Silodosin hydroxylated metabolite Oxidation - Hydroxylation Silodosin [1]
MR002260 Silodosin Silodosin N-dealkylated metabolite Oxidation - N-Dealkylation Silodosin [1]
MR002261 Silodosin Silodosin sulfated metabolite Conjugation - Sulfation Silodosin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002255 KMD-3241 KMD-3241 glucuronide Conjugation - Glucuronidation Silodosin [1]
MR002254 KMD-3241 KMD-3295 Oxidation - Oxidation Silodosin [1]
References
1 In vivo metabolic investigation of silodosin using UHPLC-QTOF-MS/MS and in silico toxicological screening of its metabolites J Mass Spectrom. 2016 Oct;51(10):867-882. doi: 10.1002/jms.3795.

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