Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002265)
Formula
SVG example
Reactant Siponimod metabolite M5 Product Siponimod metabolite M3
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009618 BAF-312 Siponimod M5 Oxidation - Hydroxylation BAF-312 [1]
MR002269 Siponimod Siponimod metabolite M5 Unclear Siponimod [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009619 Siponimod M5 Siponimod M4a Oxidation - Sulfonation BAF-312 [1]
MR002264 Siponimod metabolite M5 Siponimod metabolite M4a Unclear Siponimod [1]
References
1 Metabolism and disposition of siponimod, a novel selective S1P1/S1P5 agonist, in healthy volunteers and in vitro identification of human cytochrome P450 enzymes involved in its oxidative metabolism. Drug Metab Dispos. 2018 Jul;46(7):1001-1013.

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