Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009618)
Formula
CYP3A4 ...
SVG example
Hydroxylation
Reactant BAF-312 Product Siponimod M5
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009621 BAF-312 Siponimod M1 Unclear - Unclear BAF-312 [1]
MR009622 BAF-312 Siponimod M17 Unclear - Unclear BAF-312 [1]
MR009611 BAF-312 Siponimod M2 Unclear - Unclear BAF-312 [1]
MR009616 BAF-312 Siponimod M6 Oxidation - Hydroxylation BAF-312 [1]
MR009614 BAF-312 Siponimod M7 Oxidation - Hydroxylation BAF-312 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002269 Siponimod Siponimod metabolite M5 Unclear Siponimod [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009620 Siponimod M5 Siponimod M3 Conjugation - Glucuronidation BAF-312 [1]
MR009619 Siponimod M5 Siponimod M4a Oxidation - Sulfonation BAF-312 [1]
MR002265 Siponimod metabolite M5 Siponimod metabolite M3 Unclear Siponimod [1]
MR002264 Siponimod metabolite M5 Siponimod metabolite M4a Unclear Siponimod [1]
References
1 Metabolism and disposition of siponimod, a novel selective S1P1/S1P5 agonist, in healthy volunteers and in vitro identification of human cytochrome P450 enzymes involved in its oxidative metabolism. Drug Metab Dispos. 2018 Jul;46(7):1001-1013.

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