Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002326)
Formula
CYP3A4 ...
SVG example
Deamination
Reactant Tacrolimus Product 15-O-Desmethyltacrolimus
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Deamination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002322 Tacrolimus 12-hydroxy tacrolimus Oxidation - Deamination Tacrolimus [1]
MR002319 Tacrolimus 13-demethyl tacrolimus Oxidation - Deamination Tacrolimus [1]
MR002325 Tacrolimus 13-O-Desmethyltacrolimus Oxidation - Deamination Tacrolimus [1]
MR002323 Tacrolimus 15,31-didemethyl tacrolimus Oxidation - Deamination Tacrolimus [1]
MR002321 Tacrolimus 15-demethyl tacrolimus Oxidation - Deamination Tacrolimus [1]
MR002320 Tacrolimus 31-demethyl tacrolimus Oxidation - Deamination Tacrolimus [1]
MR002324 Tacrolimus 31-O-Demethyltacrolimus Oxidation - Deamination Tacrolimus [1]
References
1 Metabolism of tacrolimus (FK506) and recent topics in clinical pharmacokinetics Drug Metab Pharmacokinet. 2007 Oct;22(5):328-35. doi: 10.2133/dmpk.22.328.

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