Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002332)
Formula Reactant N-desmethyl tapentadol Product N-desmethyltapentadol-O-sulfate
Reactant Info Product Info
Metabolic Enzyme Adenosine aminohydrolase (ADA) DME Info
Metabolic Type Oxidation - Deamination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002334 Tapentadol N-desmethyl tapentadol Unclear Tapentadol [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002331 N-desmethyl tapentadol N-Demethyltapentadol-O-glucuronide Conjugation - Conjugation Tapentadol [2], [3]
References
1 Investigations into the drug-drug interaction potential of tapentadol in human liver microsomes and fresh human hepatocytes. Drug Metab Lett. 2008 Jan;2(1):67-75.
2 LABEL:UCYNTA- tapentadol hydrochloride tablet, film coated
3 A case report on fatal intoxication by tapentadol: Study of distribution and metabolism Forensic Sci Int. 2021 Jul;324:110825. doi: 10.1016/j.forsciint.2021.110825.

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