Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002334)
Formula
CYP2C9 ...
SVG example
Reactant Tapentadol Product N-desmethyl tapentadol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002335 Tapentadol hydroxy tapentado Oxidation - Hydroxylation Tapentadol [1]
MR002336 Tapentadol Tapentadol O-sulfate Conjugation - Conjugation Tapentadol [2], [1], [3]
MR002337 Tapentadol Tapentadol-O-glucuronide Conjugation - Conjugation Tapentadol [1], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002331 N-desmethyl tapentadol N-Demethyltapentadol-O-glucuronide Conjugation - Conjugation Tapentadol [5], [3]
MR002332 N-desmethyl tapentadol N-desmethyltapentadol-O-sulfate Oxidation - Deamination Tapentadol [3], [3]
References
1 Investigations into the drug-drug interaction potential of tapentadol in human liver microsomes and fresh human hepatocytes. Drug Metab Lett. 2008 Jan;2(1):67-75.
2 On the Molecular Basis Underlying the Metabolism of Tapentadol Through Sulfation Eur J Drug Metab Pharmacokinet. 2017 Oct;42(5):793-800. doi: 10.1007/s13318-016-0392-8.
3 A case report on fatal intoxication by tapentadol: Study of distribution and metabolism Forensic Sci Int. 2021 Jul;324:110825. doi: 10.1016/j.forsciint.2021.110825.
4 In vitro and in vivo characterization of tapentadol metabolites Methods Find Exp Clin Pharmacol. 2010 Jan-Feb;32(1):31-8. doi: 10.1358/mf.2010.32.1.1434165.
5 LABEL:UCYNTA- tapentadol hydrochloride tablet, film coated

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