Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002348)
Formula
LE
SVG example
Hydrolysis
Reactant Tazarotene Product Tazarotenic acid
Reactant Info Product Info
Metabolic Enzyme Liver esterases (LE) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002349 Tazarotene AGN 190832 Oxidation - Oxidation Tazarotene [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002343 Tazarotenic acid AGN 190844 Oxidation - Oxidation Tazarotene [1], [2], [3]
References
1 Clinical pharmacokinetics and drug metabolism of tazarotene: a novel topical treatment for acne and psoriasis Clin Pharmacokinet. 1999 Oct;37(4):273-87. doi: 10.2165/00003088-199937040-00001.
2 Cytochrome P450 2C8 and flavin-containing monooxygenases are involved in the metabolism of tazarotenic acid in humans. Drug Metab Dispos. 2003 Apr;31(4):476-81.
3 LABEL:AZAROTENE aerosol, foam

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