Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002371)
Formula Reactant Telithromycin Product Telithromycin metabolite M10b
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 (CYP) DME Info
Metabolic Type Oxidation - Deamination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002373 Telithromycin RU 72365 Oxidation - Demethylation Telithromycin [1], [2]
MR002370 Telithromycin RU 76363 Hydrolysis - Hydrolysis Telithromycin [1]
MR002374 Telithromycin RU 76584 Oxidation - Oxidation Telithromycin [1], [2]
MR002372 Telithromycin Telithromycin metabolite M11b Oxidation - Deamination Telithromycin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002367 Telithromycin metabolite M10b Telithromycin metabolite M13 Unclear Telithromycin [1]
MR002366 Telithromycin metabolite M10b Telithromycin metabolite M4'b Unclear Telithromycin [1]
References
1 Clinical pharmacokinetics of telithromycin, the first ketolide antibacterial. Clin Pharmacokinet. 2005;44(9):915-34.
2 Verapamil toxicity resulting from a probable interaction with telithromycin. Ann Pharmacother. 2005 Feb;39(2):357-60.

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