Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002373)
Formula
SVG example
Demethylation
Reactant Telithromycin Product RU 72365
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002370 Telithromycin RU 76363 Hydrolysis - Hydrolysis Telithromycin [1]
MR002374 Telithromycin RU 76584 Oxidation - Oxidation Telithromycin [1], [2]
MR002371 Telithromycin Telithromycin metabolite M10b Oxidation - Deamination Telithromycin [1]
MR002372 Telithromycin Telithromycin metabolite M11b Oxidation - Deamination Telithromycin [1]
References
1 Clinical pharmacokinetics of telithromycin, the first ketolide antibacterial. Clin Pharmacokinet. 2005;44(9):915-34.
2 Verapamil toxicity resulting from a probable interaction with telithromycin. Ann Pharmacother. 2005 Feb;39(2):357-60.

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