Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002374)
Formula
CYP3A4 ...
SVG example
Oxidation
Reactant Telithromycin Product RU 76584
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A (CYP1A) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002373 Telithromycin RU 72365 Oxidation - Demethylation Telithromycin [1], [2]
MR002370 Telithromycin RU 76363 Hydrolysis - Hydrolysis Telithromycin [1]
MR002371 Telithromycin Telithromycin metabolite M10b Oxidation - Deamination Telithromycin [1]
MR002372 Telithromycin Telithromycin metabolite M11b Oxidation - Deamination Telithromycin [1]
References
1 Clinical pharmacokinetics of telithromycin, the first ketolide antibacterial. Clin Pharmacokinet. 2005;44(9):915-34.
2 Verapamil toxicity resulting from a probable interaction with telithromycin. Ann Pharmacother. 2005 Feb;39(2):357-60.

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