Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002377)
Formula Reactant Temazepam Product O-conjugate of temazepam
Reactant Info Product Info
Metabolic Type Conjugation - Conjugation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002378 Temazepam Oxazepam Oxidation - Demethylation Temazepam [1], [2]
MR000823 Temazepam Oxazepam Oxidation - N-Demethylation Diazepam [3], [4]
MR000822 Temazepam Temazepam O-glucuronide Conjugation - O-Glucuronidation Diazepam [3], [5]
MR001326 Temazepam Oxazepam Oxidation - Demethylation Ketazolam [6]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002376 O-conjugate of temazepam Temazepam metabolite M1 Oxidation - Demethylation Temazepam [2], [7]
References
1 Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: role of CYP2B6, 2C19 and the 3A subfamily. Xenobiotica. 1996 Nov;26(11):1155-66.
2 Pharmacokinetics and metabolism of temazepam in man and several animal species Br J Clin Pharmacol. 1979;8(1):23S-29S. doi: 10.1111/j.1365-2125.1979.tb00451.x.
3 DrugBank(Pharmacology-Metabolism)Diazepam
4 Kinetic disposition of diazepam and its metabolites after intravenous administration of diazepam in the horse: Relevance for doping control. J Vet Pharmacol Ther. 2021 Sep;44(5):733-744. doi: 10.1111/jvp.12991.
5 Pharmacokinetics of Diazepam and Its Metabolites in Urine of Chinese Participants. Drugs R D. 2022 Mar;22(1):43-50. doi: 10.1007/s40268-021-00375-y.
6 Urinary diazepam metabolite distribution in a chronic pain population J Anal Toxicol. 2014 Apr;38(3):135-42. doi: 10.1093/jat/bku001.
7 Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives. Biochem J. 1999 Jun 15;340 ( Pt 3):845-53.

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