Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000822)
Formula Reactant Temazepam Product Temazepam O-glucuronide
Reactant Info Product Info
Metabolic Type Conjugation - O-Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002377 Temazepam O-conjugate of temazepam Conjugation - Conjugation Temazepam [1]
MR002378 Temazepam Oxazepam Oxidation - Demethylation Temazepam [2], [1]
MR000823 Temazepam Oxazepam Oxidation - N-Demethylation Diazepam [3], [4]
MR001326 Temazepam Oxazepam Oxidation - Demethylation Ketazolam [5]
References
1 Pharmacokinetics and metabolism of temazepam in man and several animal species Br J Clin Pharmacol. 1979;8(1):23S-29S. doi: 10.1111/j.1365-2125.1979.tb00451.x.
2 Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: role of CYP2B6, 2C19 and the 3A subfamily. Xenobiotica. 1996 Nov;26(11):1155-66.
3 DrugBank(Pharmacology-Metabolism)Diazepam
4 Kinetic disposition of diazepam and its metabolites after intravenous administration of diazepam in the horse: Relevance for doping control. J Vet Pharmacol Ther. 2021 Sep;44(5):733-744. doi: 10.1111/jvp.12991.
5 Urinary diazepam metabolite distribution in a chronic pain population J Anal Toxicol. 2014 Apr;38(3):135-42. doi: 10.1093/jat/bku001.

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