Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002378)
Formula
CYP3A4 ...
SVG example
Demethylation
Reactant Temazepam Product Oxazepam
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002377 Temazepam O-conjugate of temazepam Conjugation - Conjugation Temazepam [1]
MR000822 Temazepam Temazepam O-glucuronide Conjugation - O-Glucuronidation Diazepam [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011244 Chlordiazepoxide Oxazepam Unclear - Unclear Chlordiazepoxide [4]
MR005297 Clorazepic acid Oxazepam Unclear Clorazepic acid [5]
MR000820 Diazepam Oxazepam Oxidation - N-Demethylation Diazepam [2], [3], [6]
MR004426 Nordazepam Oxazepam Oxidation - C3-hydroxylation Nordazepam [7], [8]
MR011028 3-hydroxy-hazaepam Oxazepam Unclear - Unclear Halazepam [9]
MR002104 3-hydroxyprazepam Oxazepam Oxidation - N-Dealkylation Prazepam [10], [11]
MR011026 Desmethyl-diazepam Oxazepam Unclear - Unclear Halazepam [9]
MR000825 Nordazepam Oxazepam Unclear Diazepam [12], [3], [6]
MR002111 Nordazepam Oxazepam Oxidation - Hydroxylation Prazepam [13], [10], [11]
MR005846 Medazepam metabolite Oxazepam Unclear Medazepam [14], [15]
MR001327 Nordazepam Oxazepam Oxidation - Hydroxylation Ketazolam [16]
MR005841 Medazepam metabolite Oxazepam Unclear Medazepam [14], [17]
⏷ Show the Full List of MR
References
1 Pharmacokinetics and metabolism of temazepam in man and several animal species Br J Clin Pharmacol. 1979;8(1):23S-29S. doi: 10.1111/j.1365-2125.1979.tb00451.x.
2 DrugBank(Pharmacology-Metabolism)Diazepam
3 Pharmacokinetics of Diazepam and Its Metabolites in Urine of Chinese Participants. Drugs R D. 2022 Mar;22(1):43-50. doi: 10.1007/s40268-021-00375-y.
4 Biological half-life of chlordiazepoxide and its metabolite, demoxepam, in man
5 Determination of clorazepate and its major metabolites in blood and urine by electron capture gas-liquid chromatography
6 Kinetic disposition of diazepam and its metabolites after intravenous administration of diazepam in the horse: Relevance for doping control. J Vet Pharmacol Ther. 2021 Sep;44(5):733-744. doi: 10.1111/jvp.12991.
7 Kinetics of sequential metabolism. I. Formation and metabolism of oxazepam from nordiazepam and temazepam in the perfused murine liver
8 Kinetics of sequential metabolism. II. Formation and metabolism of nordiazepam and oxazepam from diazepam in the perfused murine liver
9 Pharmacokinetics and metabolism of halazepam in naive and dependent dogs
10 Prazepam metabolism by man Clin Pharmacol Ther. 1970 Nov-Dec;11(6):890-7. doi: 10.1002/cpt1970116890.
11 Prazepam metabolites in dog urine J Pharm Sci. 1970 Mar;59(3):322-5. doi: 10.1002/jps.2600590309.
12 Study on the Pharmacokinetics of Diazepam and Its Metabolites in Blood of Chinese People Eur J Drug Metab Pharmacokinet. 2020 Aug;45(4):477-485. doi: 10.1007/s13318-020-00614-8.
13 Metabolic profile of oxazepam and related benzodiazepines: clinical and forensic aspects. Drug Metab Rev. 2017 Nov;49(4):451-463.
14 Metabolism of 14C-medazepam hydrochloride in dog, rat and man
15 Plasma concentrations of medazepam and its metabolites after oral administration
16 Urinary diazepam metabolite distribution in a chronic pain population J Anal Toxicol. 2014 Apr;38(3):135-42. doi: 10.1093/jat/bku001.
17 Further studies on medazepam metabolism in the rat

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