Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002389)
Formula
SVG example
Hydrolysis
Reactant Temsirolimus Product Sirolimus
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002388 Temsirolimus . Unclear Temsirolimus [1]
MR002382 Temsirolimus 11-hydroxyl temsirolimus Unclear Temsirolimus [2]
MR002386 Temsirolimus 25-hydroxy temsirolimus Oxidation - Hydroxylation Temsirolimus [3]
MR002385 Temsirolimus 27-O-desmethyl temsirolimus Oxidation - O-Demethylation Temsirolimus [3]
MR002384 Temsirolimus 32-O-desmethyl temsirolimus Unclear Temsirolimus [2]
MR002381 Temsirolimus 35-hydroxyl temsirolimus Unclear Temsirolimus [2]
MR002380 Temsirolimus 36-hydroxyl temsirolimus Unclear Temsirolimus [2]
MR002387 Temsirolimus Hydroxy-piperidine temsirolimus Oxidation - Hydroxylation Temsirolimus [3]
MR002383 Temsirolimus N-oxide temsirolimus Unclear Temsirolimus [2]
References
1 Drug Interactions Flockhart Table:Docetaxel
2 In vitro metabolic study of temsirolimus: preparation, isolation, and identification of the metabolites Drug Metab Dispos. 2007 Sep;35(9):1554-63. doi: 10.1124/dmd.107.014746.
3 Temsirolimus metabolic pathways revisited Xenobiotica. 2020 Jun;50(6):640-653. doi: 10.1080/00498254.2019.1678793.

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