Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002450)
Formula
SVG example
Sulfation
Reactant 4'-OH-triamterene Product 4'-OH-triamterene sulfate metabolite
Reactant Info Product Info
Metabolic Enzyme Sulfotransferase (SULT) DME Info
Metabolic Type Conjugation - Sulfation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002451 Triamterene 4'-OH-triamterene Oxidation - Hydroxylation Triamterene [1], [2]
References
1 Extraction of structure-activity relationship information from high-throughput screening data Curr Med Chem. 2009;16(31):4049-57. doi: 10.2174/092986709789378189.
2 Rate-limiting biotransformation of triamterene is mediated by CYP1A2. Int J Clin Pharmacol Ther. 2005 Jul;43(7):327-34.

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