Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002460)
Formula
CYP3A4 ...
SVG example
C-Oxidation
Reactant Trimethoprim Product Calpha-OH-TMP
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Metabolic Type Oxidation - C-Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002457 Trimethoprim 1-NO-TMP Oxidation - N-Oxidation Trimethoprim [1]
MR002458 Trimethoprim 3-Desmethyl-TMP Oxidation - O-Demethylation Trimethoprim [1]
MR002456 Trimethoprim 3-NO-TMP Oxidation - N-Oxidation Trimethoprim [1]
MR002459 Trimethoprim 4-Desmethyl-TMP Oxidation - O-Demethylation Trimethoprim [1]
MR002461 Trimethoprim Calpha-NAC-TMP Oxidation - C-Oxidation Trimethoprim [1]
References
1 In Vitro Hepatic Oxidative Biotransformation of Trimethoprim Drug Metab Dispos. 2015 Sep;43(9):1372-80. doi: 10.1124/dmd.115.065193.

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