Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002464)
Formula
SVG example
Sulfation
Reactant Troglitazone Product Troglitazone sulfate metabolite
Reactant Info Product Info
Metabolic Type Conjugation - Sulfation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002465 Troglitazone Troglitazone glucuronide metabolite Conjugation - Glucuronidation Troglitazone [1], [2]
MR002466 Troglitazone Troglitazone Quinone Oxidation - Oxidation Troglitazone [3], [4]
References
1 Clinical pharmacokinetics of troglitazone Clin Pharmacokinet. 1999 Aug;37(2):91-104. doi: 10.2165/00003088-199937020-00001.
2 Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos. 2002 Dec;30(12):1462-9.
3 Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes. Drug Metab Dispos. 1999 Nov;27(11):1260-6.
4 Intestinal motility and its disorders Scand J Urol Nephrol Suppl. 1992;142:18-21.

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