Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002466)
Formula
CYP2C8 ...
SVG example
Oxidation
Reactant Troglitazone Product Troglitazone Quinone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002465 Troglitazone Troglitazone glucuronide metabolite Conjugation - Glucuronidation Troglitazone [1], [2]
MR002464 Troglitazone Troglitazone sulfate metabolite Conjugation - Sulfation Troglitazone [1]
References
1 Clinical pharmacokinetics of troglitazone Clin Pharmacokinet. 1999 Aug;37(2):91-104. doi: 10.2165/00003088-199937020-00001.
2 Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos. 2002 Dec;30(12):1462-9.

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