Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002510)
Formula Reactant Vemurafenib Product Vemurafenib intermediary metabolite
Reactant Info Product Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002508 Vemurafenib Hydroxyvemurafenib Oxidation - Hydroxylation Vemurafenib [1]
MR002509 Vemurafenib Vemurafenib glucuronide Conjugation - Glucuronidation Vemurafenib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002507 Vemurafenib intermediary metabolite Secondary metabolite of vemurafenib Hydrolysis - Hydrolysis Vemurafenib [2]
MR002506 Vemurafenib intermediary metabolite Secondary metabolite of vemurafenib alternative Oxidation - Dehalogenation Vemurafenib [2]
References
1 Novel rapid liquid chromatography tandem masspectrometry method for vemurafenib and metabolites in human plasma, including metabolite concentrations at steady state Biomed Chromatogr. 2016 Aug;30(8):1234-9. doi: 10.1002/bmc.3672.
2 A single-dose mass balance and metabolite-profiling study of vemurafenib in patients with metastatic melanoma Pharmacol Res Perspect. 2015 Mar;3(2):e00113. doi: 10.1002/prp2.113.

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