Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002508)
Formula Reactant Vemurafenib Product Hydroxyvemurafenib
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002509 Vemurafenib Vemurafenib glucuronide Conjugation - Glucuronidation Vemurafenib [1]
MR002510 Vemurafenib Vemurafenib intermediary metabolite Hydrolysis - Hydrolysis Vemurafenib [2]
References
1 Novel rapid liquid chromatography tandem masspectrometry method for vemurafenib and metabolites in human plasma, including metabolite concentrations at steady state Biomed Chromatogr. 2016 Aug;30(8):1234-9. doi: 10.1002/bmc.3672.
2 A single-dose mass balance and metabolite-profiling study of vemurafenib in patients with metastatic melanoma Pharmacol Res Perspect. 2015 Mar;3(2):e00113. doi: 10.1002/prp2.113.

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