Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002512)
Formula
CYP2C19 ...
SVG example
Hydroxylation
Reactant Cannabidiol Product 7-hydroxy-cannabidiol
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002515 Cannabidiol 1''-Hydroxycannabidiol Oxidation - Hydroxylation Cannabidiol [1]
MR002516 Cannabidiol 2''-Hydroxycannabidiol Oxidation - Hydroxylation Cannabidiol [1]
MR002517 Cannabidiol 3''-Hydroxycannabidiol Oxidation - Hydroxylation Cannabidiol [1]
MR002518 Cannabidiol 4''-Hydroxycannabidiol Oxidation - Hydroxylation Cannabidiol [1]
MR002519 Cannabidiol 5''-Hydroxycannabidiol Oxidation - Hydroxylation Cannabidiol [1]
MR002514 Cannabidiol 6alpha-Hydroxycannabidiol Oxidation - Hydroxylation Cannabidiol [1]
MR002513 Cannabidiol 6beta-Hydroxycannabidiol Oxidation - Hydroxylation Cannabidiol [1]
MR002520 Cannabidiol Cannabidiol-O-Glucuronide Conjugation - Glucuronidation Cannabidiol [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003645 CBD 7-OH-CBD Unclear GW-1000 [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002511 7-hydroxy-cannabidiol 7-Carboxy-Cannabidiol Unclear Cannabidiol [1]
MR003647 7-OH-CBD 7-OH-CBD-glucuronide Unclear GW-1000 [2]
MR003646 7-OH-CBD CBD-7-oic acid Oxidation - Oxidationn GW-1000 [2]
References
1 Cytochrome P450-Catalyzed Metabolism of Cannabidiol to the Active Metabolite 7-Hydroxy-Cannabidiol Drug Metab Dispos. 2021 Oct;49(10):882-891. doi: 10.1124/dmd.120.000350.
2 Techniques and technologies for the bioanalysis of Sativex?, metabolites and related compounds

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