Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002518)
Formula
SVG example
Hydroxylation
Reactant Cannabidiol Product 4''-Hydroxycannabidiol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002515 Cannabidiol 1''-Hydroxycannabidiol Oxidation - Hydroxylation Cannabidiol [1]
MR002516 Cannabidiol 2''-Hydroxycannabidiol Oxidation - Hydroxylation Cannabidiol [1]
MR002517 Cannabidiol 3''-Hydroxycannabidiol Oxidation - Hydroxylation Cannabidiol [1]
MR002519 Cannabidiol 5''-Hydroxycannabidiol Oxidation - Hydroxylation Cannabidiol [1]
MR002514 Cannabidiol 6alpha-Hydroxycannabidiol Oxidation - Hydroxylation Cannabidiol [1]
MR002513 Cannabidiol 6beta-Hydroxycannabidiol Oxidation - Hydroxylation Cannabidiol [1]
MR002512 Cannabidiol 7-hydroxy-cannabidiol Oxidation - Hydroxylation Cannabidiol [1]
MR002520 Cannabidiol Cannabidiol-O-Glucuronide Conjugation - Glucuronidation Cannabidiol [1]
References
1 Cytochrome P450-Catalyzed Metabolism of Cannabidiol to the Active Metabolite 7-Hydroxy-Cannabidiol Drug Metab Dispos. 2021 Oct;49(10):882-891. doi: 10.1124/dmd.120.000350.

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