Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002541)
Formula
CYP3A4 ...
SVG example
Oxidation
Reactant Chenodeoxycholic acid Product 7alpha-hydroxy-3-oxo-5beta-cholan-24-oic Acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002546 Chenodeoxycholic acid Chenodeoxycholic acid glucuronide Unclear Chenodeoxycholic acid [1]
MR002543 Chenodeoxycholic acid Chenodeoxycholic acid sulfolithocholyl metabolite Unclear Chenodeoxycholic acid [2]
MR002545 Chenodeoxycholic acid Cholic acid Unclear Chenodeoxycholic acid [3]
MR002542 Chenodeoxycholic acid Gamma-muricholic acid Unclear Chenodeoxycholic acid [2]
MR002540 Chenodeoxycholic acid Lithocholic acid Unclear Chenodeoxycholic acid [2]
MR002544 Chenodeoxycholic acid Taurine Unclear Chenodeoxycholic acid [2]
References
1 Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver. Hepatology. 2006 Nov;44(5):1158-70.
2 Identification of human hepatic cytochrome p450 enzymes involved in the biotransformation of cholic and chenodeoxycholic acid. Drug Metab Dispos. 2008 Oct;36(10):1983-91.
3 Conversion of chenodeoxycholic acid to cholic acid by human CYP8B1. Biol Chem. 2019 Apr 24;400(5):625-628.

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