Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002545)
Formula
SVG example
Reactant Chenodeoxycholic acid Product Cholic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 8B1 (CYP8B1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002541 Chenodeoxycholic acid 7alpha-hydroxy-3-oxo-5beta-cholan-24-oic Acid Oxidation - Oxidation Chenodeoxycholic acid [1]
MR002546 Chenodeoxycholic acid Chenodeoxycholic acid glucuronide Unclear Chenodeoxycholic acid [2]
MR002543 Chenodeoxycholic acid Chenodeoxycholic acid sulfolithocholyl metabolite Unclear Chenodeoxycholic acid [1]
MR002542 Chenodeoxycholic acid Gamma-muricholic acid Unclear Chenodeoxycholic acid [1]
MR002540 Chenodeoxycholic acid Lithocholic acid Unclear Chenodeoxycholic acid [1]
MR002544 Chenodeoxycholic acid Taurine Unclear Chenodeoxycholic acid [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005331 Dehydrocholic acid Cholic acid Reduction - Reduction Dehydrocholic acid [3], [4]
MR013677 Deoxycholic acid CA Oxidation - 7-hydroxylation Deoxycholic acid [5]
MR006022 Oxolithocholic acid CA Unclear Oxolithocholic acid [6]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006023 CA 7-oxo-DCA Unclear Oxolithocholic acid [6]
References
1 Identification of human hepatic cytochrome p450 enzymes involved in the biotransformation of cholic and chenodeoxycholic acid. Drug Metab Dispos. 2008 Oct;36(10):1983-91.
2 Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver. Hepatology. 2006 Nov;44(5):1158-70.
3 Triketocholanoic (dehydrocholic) acid. Hepatic metabolism and effect on bile flow and biliary lipid secretion in man
4 Identification, cloning, heterologous expression, and characterization of a NADPH-dependent 7beta-hydroxysteroid dehydrogenase from Collinsella aerofaciens. Appl Microbiol Biotechnol. 2011 Apr;90(1):127-35.
5 Deoxycholic acid transformations catalyzed by selected filamentous fungi
6 Metabolism of oxo-bile acids and characterization of recombinant 12alpha-hydroxysteroid dehydrogenases from bile acid 7alpha-dehydroxylating human gut bacteria. Appl Environ Microbiol. 2018 May 1;84(10). pii: e00235-18.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.