Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002570)
Formula Reactant Cabazitaxel metabolite M08b Product RPR111026
Reactant Info Product Info
Metabolic Type Oxidation - 10-O-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002569 Cabazitaxel metabolite M07 Cabazitaxel metabolite M08b Oxidation - Hydroxylation Cabazitaxel [1]
MR002574 Cabazitaxel metabolite M2 Cabazitaxel metabolite M08b Oxidation - Cleavage Cabazitaxel [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002571 Cabazitaxel metabolite M08b Cabazitaxel metabolite M02a Oxidation - Hydroxylation Cabazitaxel [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002563 RPR104952 RPR111026 Oxidation - Hydroxylation Cabazitaxel [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002564 RPR111026 Cabazitaxel metabolite M09b Oxidation - Hydroxylation Cabazitaxel [1]
MR002565 RPR111026 RPR104943 Oxidation - Hydroxylation Cabazitaxel [1]
References
1 A phase I open-label study investigating the disposition of [14C]-cabazitaxel in patients with advanced solid tumors Anticancer Drugs. 2015 Mar;26(3):350-8. doi: 10.1097/CAD.0000000000000185.

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