Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002574)
Formula Reactant Cabazitaxel metabolite M2 Product Cabazitaxel metabolite M08b
Reactant Info Product Info
Metabolic Type Oxidation - Cleavage
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002573 Cabazitaxel metabolite M1 Cabazitaxel metabolite M2 Oxidation - Hydroxylation Cabazitaxel [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002569 Cabazitaxel metabolite M07 Cabazitaxel metabolite M08b Oxidation - Hydroxylation Cabazitaxel [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002571 Cabazitaxel metabolite M08b Cabazitaxel metabolite M02a Oxidation - Hydroxylation Cabazitaxel [1]
MR002570 Cabazitaxel metabolite M08b RPR111026 Oxidation - 10-O-Demethylation Cabazitaxel [1]
References
1 A phase I open-label study investigating the disposition of [14C]-cabazitaxel in patients with advanced solid tumors Anticancer Drugs. 2015 Mar;26(3):350-8. doi: 10.1097/CAD.0000000000000185.

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