Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002613)
Formula
SVG example
4'-Hydroxylation
Reactant Diclofenac sodium Product 4'-hydroxydiclofenac
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - 4'-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002612 Diclofenac sodium 3'-hydroxydiclofenac Oxidation - 3'-Hydroxylation Diclofenac sodium [1], [2]
MR002614 Diclofenac sodium 5-hydroxy diclofenac Oxidation - 5-Hydroxylation Diclofenac sodium [1], [2]
MR002616 Diclofenac sodium Diclofenac 2',3'-oxide Unclear Diclofenac sodium [3]
MR002618 Diclofenac sodium Diclofenac acyl glucuronide Conjugation - Glucuronidation Diclofenac sodium [3]
MR002615 Diclofenac sodium Diclofenac o-imine methine Oxidation - Oxidative Decarboxylation Diclofenac sodium [3]
MR002617 Diclofenac sodium Diclofenac radical Oxidation - Oxidation Diclofenac sodium [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003369 4'-hydroxyaceclofenac 4'-hydroxydiclofenac Unclear Aceclofenac [4]
MR003370 Diclofenac 4'-hydroxydiclofenac Unclear Aceclofenac [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002602 4'-hydroxydiclofenac 4'-hydroxy-2'-glutathione conjugated monoclofenac Conjugation - Glutathione Conjugation Diclofenac sodium [5]
MR002603 4'-hydroxydiclofenac 4'-hydroxy-3'-glutathione conjugated diclofenac Conjugation - Glutathione Conjugation Diclofenac sodium [3]
References
1 Plasma and synovial fluid concentrations of diclofenac sodium and its major hydroxylated metabolites during long-term treatment of rheumatoid arthritis Eur J Clin Pharmacol. 1983;25(3):389-94. doi: 10.1007/BF01037953.
2 Simultaneous determination of diclofenac sodium and its hydroxy metabolites by capillary column gas chromatography with electron-capture detection J Chromatogr. 1981 Nov 6;217:263-71. doi: 10.1016/s0021-9673(00)88081-4.
3 DrugBank(Pharmacology-Metabolism)Diclofenac sodium
4 Modeling of aceclofenac metabolism to major metabolites in healthy volunteers Drug Metab Pharmacokinet. 2016 Dec;31(6):458-463. doi: 10.1016/j.dmpk.2016.10.001.
5 Clinical pharmacokinetics of diclofenac. Therapeutic insights and pitfalls Clin Pharmacokinet. 1997 Sep;33(3):184-213. doi: 10.2165/00003088-199733030-00003.

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