Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002615)
Formula Reactant Diclofenac sodium Product Diclofenac o-imine methine
Reactant Info Product Info
Metabolic Type Oxidation - Oxidative Decarboxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002612 Diclofenac sodium 3'-hydroxydiclofenac Oxidation - 3'-Hydroxylation Diclofenac sodium [1], [2]
MR002613 Diclofenac sodium 4'-hydroxydiclofenac Oxidation - 4'-Hydroxylation Diclofenac sodium [3], [1], [2]
MR002614 Diclofenac sodium 5-hydroxy diclofenac Oxidation - 5-Hydroxylation Diclofenac sodium [1], [2]
MR002616 Diclofenac sodium Diclofenac 2',3'-oxide Unclear Diclofenac sodium [4]
MR002618 Diclofenac sodium Diclofenac acyl glucuronide Conjugation - Glucuronidation Diclofenac sodium [4]
MR002617 Diclofenac sodium Diclofenac radical Oxidation - Oxidation Diclofenac sodium [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002608 Diclofenac o-imine methine 2-(2,6-dichlorophenylamino)-benzyl-S-thioether glutathione Conjugation - Glutathione Conjugation Diclofenac sodium [4]
References
1 Plasma and synovial fluid concentrations of diclofenac sodium and its major hydroxylated metabolites during long-term treatment of rheumatoid arthritis Eur J Clin Pharmacol. 1983;25(3):389-94. doi: 10.1007/BF01037953.
2 Simultaneous determination of diclofenac sodium and its hydroxy metabolites by capillary column gas chromatography with electron-capture detection J Chromatogr. 1981 Nov 6;217:263-71. doi: 10.1016/s0021-9673(00)88081-4.
3 Clinical pharmacokinetics of diclofenac. Therapeutic insights and pitfalls Clin Pharmacokinet. 1997 Sep;33(3):184-213. doi: 10.2165/00003088-199733030-00003.
4 DrugBank(Pharmacology-Metabolism)Diclofenac sodium

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