Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002623)
Formula
SVG example
Reactant Adefovir Product Adefovir Dipivoxil(ADV-DP)2
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011014 Adefovir Cyclic prodrug of Adefovir 3 Unclear - Unclear adefovir [1]
MR000062 Adefovir Adefovir monophosphate Other reaction - Phosphorylation Adefovir dipivoxil [2]
MR002619 Adefovir Cyclic prodrug of Adefovir 3 Unclear ICN-2001-3 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002621 Adefovir Dipivoxil(ADV-DP)2 Adefovir Diphosphate(ADV-DP)4 Unclear ICN-2001-3 [1]
References
1 Pradefovir: a prodrug that targets adefovir to the liver for the treatment of hepatitis B J Med Chem. 2008 Feb 14;51(3):666-76. doi: 10.1021/jm7012216.
2 Effective metabolism and long intracellular half life of the anti-hepatitis B agent adefovir in hepatic cells Biochem Pharmacol. 2004 Nov 1;68(9):1825-31. doi: 10.1016/j.bcp.2004.07.010.

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