Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011014)
Formula Reactant Adefovir Product Cyclic prodrug of Adefovir 3
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011016 Adefovir Adefovir Dipivoxil Unclear - Unclear adefovir [1]
MR002623 Adefovir Adefovir Dipivoxil(ADV-DP)2 Unclear ICN-2001-3 [1]
MR000062 Adefovir Adefovir monophosphate Other reaction - Phosphorylation Adefovir dipivoxil [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011015 Cyclic prodrug of Adefovir 3 Adefovir Diphosphate Unclear - Unclear adefovir [1]
MR002620 Cyclic prodrug of Adefovir 3 Adefovir Diphosphate(ADV-DP)4 Unclear ICN-2001-3 [1]
References
1 Pradefovir: a prodrug that targets adefovir to the liver for the treatment of hepatitis B J Med Chem. 2008 Feb 14;51(3):666-76. doi: 10.1021/jm7012216.
2 Effective metabolism and long intracellular half life of the anti-hepatitis B agent adefovir in hepatic cells Biochem Pharmacol. 2004 Nov 1;68(9):1825-31. doi: 10.1016/j.bcp.2004.07.010.

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