Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004105)
Formula
SVG example
Hydrolyzationn
Reactant Conjugated estrogens Product 4-Hydroxyestradiol
Reactant Info Product Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004108 Conjugated estrogens 16-alpha-hydroxy-17-beta-dihydro equilin Unclear Conjugated estrogens [1]
MR004109 Conjugated estrogens 16-alpha-hydroxy-17-beta-dihydroequilenin Unclear Conjugated estrogens [1]
MR004107 Conjugated estrogens 17-ketosteroid-16-alpha-hydroxyestrone Oxidation - Oxidationn Conjugated estrogens [1]
MR004103 Conjugated estrogens 2-hydroxy equilin Oxidation - Hydrolyzationn Conjugated estrogens [1]
MR004104 Conjugated estrogens 2-hydroxyestradiol Oxidation - Hydrolyzationn Conjugated estrogens [1]
MR004106 Conjugated estrogens 4-hydroxy equilin Oxidation - Hydrolyzationn Conjugated estrogens [1]
MR004101 Conjugated estrogens Estrone Reduction - Reduction Conjugated estrogens [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013318 E-3A 4-Hydroxyestradiol Unclear E-3A [3]
MR013316 4-hydroxyestrone 4-Hydroxyestradiol Unclear E-3A [4]
MR002626 Estradiol 4-hydroxyestradiol Unclear Estradiol acetate [4]
MR002649 Estradiol 4-hydroxyestradiol Oxidation - Hydroxylation Estradiol cypionate [4]
MR002672 Estradiol 4-hydroxyestradiol Oxidation - Hydroxylation Estradiol valerate [4]
MR002643 4-hydroxyestrone 4-hydroxyestradiol Unclear Estradiol acetate [5]
MR002666 4-hydroxyestrone 4-hydroxyestradiol Unclear Estradiol cypionate [5]
MR002689 4-hydroxyestrone 4-hydroxyestradiol Unclear Estradiol valerate [5]
⏷ Show the Full List of MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013319 4-Hydroxyestradiol 4-methoxyestradiol Unclear E-3A [3]
MR002642 4-hydroxyestradiol 4-methoxyestradiol Unclear Estradiol acetate [4]
MR002665 4-hydroxyestradiol 4-methoxyestradiol Unclear Estradiol cypionate [4]
MR002688 4-hydroxyestradiol 4-methoxyestradiol Unclear Estradiol valerate [4]
References
1 Pharmacokinetics and pharmacodynamics of conjugated equine estrogens: chemistry and metabolism
2 Conjugated estrogens and bazedoxifene
3 Cytochrome P450-mediated metabolism of estrogens and its regulation in human. Cancer Lett. 2005 Sep 28;227(2):115-24.
4 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
5 Cytochrome P450-mediated metabolism of estrogens and its regulation in human Cancer Lett. 2005 Sep 28;227(2):115-24. doi: 10.1016/j.canlet.2004.10.007.

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